5 edition of Receptor-mediated endocytosis found in the catalog.
Includes bibliographies and index.
|Statement||edited by P. Cuatrecasas and T. Roth.|
|Series||Receptors and recognition., v. 15|
|Contributions||Cuatrecasas, Pedro., Roth, T. 1932-|
|LC Classifications||QH634 .R43 1983|
|The Physical Object|
|Pagination||x, 304 p. :|
|Number of Pages||304|
|LC Control Number||83001944|
Receptor-mediated endocytosis, also known as clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, other proteins, and in some cases viruses (endocytosis), by inward budding of plasma membrane vesicles containing proteins with receptor sites specific to . Abstract. Clathrin-mediated endocytosis is the main portal of entry into the cell for many soluble and membrane molecules. Clathrin-coated vesicles are formed from the plasma membrane in a sequence of coordinated protein-lipid and protein-protein interactions, starting with adaptor-mediated recruitment of clathrin to the membrane, proceeding to clathrin polymerization and assembly into Cited by: 4.
ISBN: OCLC Number: Description: x, pages: illustrations ; 25 cm. Contents: 1 Receptor-Mediated Endocytosis: General Considerations and Morphological Approaches.- 2 The Structure of Coated Vesicles.- 3 Adsorptive Pinocytosis of Epidermal Growth Factor: Studies of its Relevance to Mitogenesis.- 4 The Binding and Internalization of Nerve Growth Factor.- 5. Describe receptor-mediated endocytosis. Receptors bind specific ligand within coated pits to form endosomes. The endosome becomes acidified and enriched with acid hydrolyses, becoming the late endosome, and ultimately lysosome.
Receptor Mediated Endocytosis (Clathrin Mediated Endocytosis) This is a type of endocytosis also known as clathrin-mediated endocytosis; It involves the internalization and recycling of receptors that are used in processes such as signal transduction (G-protein and tyrosine kinase receptors), nutrient uptake and synaptic vesicle reformation. Purchase Endocytosis and Exocytosis, Volume 4 - 1st Edition. Print Book & E-Book. ISBN ,
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Book: Cells - Molecules and Mechanisms (Wong) Receptor-mediated endocytosis of cholesterol via low-density lipoprotein. The endosomal vesicle with the LDL in it next fuses with another acidic, membrane-bound compartment.
The lysosome, at pH ~, is even more acidic than the endosome, and it also contains a large complement of acid. This volume focuses exclusively on those endocytic processes that sequester proteins by a selective, receptor-mediated mechanism.
In such an endocytic process, cell surface receptors specifically bind protein ligands and localize them to specialized invaginations of the plasma membrane.
These. Receptor-Mediated Endocytosis. In contrast to phagocytosis, which plays only specialized roles, pinocytosis is common among eukaryotic cells. The best-characterized form of this process is receptor-mediated endocytosis, which provides a mechanism for the selective uptake of specific macromolecules (Figure ).
The macromolecules to be internalized first bind to specific cell surface receptors. Receptor‐mediated drug delivery can also enable otherwise membrane‐impermeable drugs to enter target cells by receptor‐mediated endocytosis, or it can induce desirable changes in cell behavior by activating a receptor's normal signaling by: 6.
Receptor-mediated endocytosis, however, reconciles the view that biological membranes should be impervious to macromolecules with the evidence that certain mac romolecules do gain entrance into the cell. During the last few years this field has been stimulated by studies on the uptake and processing of low density lipoproteins (LDL) by cells.
This book is divided into three sections, with the first focusing on model systems of internalization. It presents pictorial illustrations of the receptor-mediated endocytosis of low-density lipoprotein via coated regions of membrane and discusses the receptor for lysosomal enzymes on the surface of.
Receptor-mediated endocytosis into the brain could also be possible through this insulin receptor present in endothelial cells. This insulin receptor is a tyrosine kinase heterotetramer receptor containing two extracellular α- and two transmembrane β-subunits. During the receptor-mediated endocytosis, that takes place in late oogenesis, the Vg receptor, a low density lipoprotein receptor (LDLR) is essential for vitellogenin uptake.
LDLRs represent a group of receptors closely related to cell surface receptors that regulate the uptake of extracellular ligands (Herz and Bock, ). Cell Import - Endocytosis. Endocytosis types. Receptor Mediated Endocytosis. Books PubMed. PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals for biomedical articles back to PubMed includes links to full text articles and other related.
Receptor-mediated endocytosis is many thousand times more efficient than simple pinocytosis in enabling the cell to acquire the macromolecules it needs. Low-Density Lipoprotein (LDL) Receptor Cells take up cholesterol by receptor-mediated endocytosis.
Receptor-mediated Endocytosis. A targeted variation of endocytosis, known as receptor-mediated endocytosis, employs receptor proteins in the plasma membrane that have a specific binding affinity for certain substances. In receptor-mediated endocytosis, as in phagocytosis, clathrin is attached to the cytoplasmic side of the plasma membrane.
Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu Rev Cell Biol. ; – Wileman T, Harding C, Stahl P.
Receptor-mediated endocytosis. Biochem J. Nov 15; (1):1– [PMC free article] Anderson RG, Brown MS, Goldstein JL. Role of the coated endocytic vesicle in the uptake of receptor-bound low Cited by: This is where endocytosis comes into picture, wherein the cell simply swallows the substance (molecule) and enters the cytoplasm.
Thus, it is through endocytosis that the substances can move inside the cell. Depending upon how endocytosis is carried out, it is classified into 3 main types, viz. phagocytosis, pinocytosis, and receptor-mediated.
However, receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles (Figure ). In this respect, the process is similar to the packaging of lysosomal enzymes by mannose 6-phosphate (M6P) in the trans-Golgi (see Figure ). As noted earlier, although most M6P receptors are localized to the trans-Golgi, some are Cited by: 5.
Willingham MC, Maxfield FR, Pastan I. Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. J Histochem Cytochem.
Aug; 28 (8)– LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. Nov; (1)– Bradford by: Receptor-mediated endocytosis is a process through which bulk amounts of specific molecules can be imported into a cell after binding to cell surface receptors.
The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake.
Geuze HJ, Slot JW, Strous GJ, Schwartz AL. The pathway of the asialoglycoprotein-ligand during receptor-mediated endocytosis: a morphological study with colloidal gold/ligand in the human hepatoma cell line, Hep G2.
Eur J Cell Biol. Nov; 32 (1)– Geuze HJ, Slot JW, Strous GJ, Peppard J, von Figura K, Hasilik A, Schwartz by: In receptor-mediated endocytosis, as in phagocytosis, clathrin is attached to the cytoplasmic side of the plasma membrane.
If uptake of a compound is dependent on receptor-mediated endocytosis and the process is ineffective, the material will not be removed from the tissue fluids or blood.
In receptor-mediated endocytosis, as in phagocytosis, clathrin attaches to the plasma membrane's cytoplasmic side. If a compound's uptake is dependent on receptor-mediated endocytosis and the process is ineffective, the material will not be removed from the tissue fluids or blood.
Instead, it will stay in those fluids and increase in concentration. Endocytosis is a type of active transport that moves particles, such as large molecules, parts of cells, and even whole cells, into a cell. There are different variations of endocytosis, but all share a common characteristic: The plasma membrane of the cell invaginates, forming a pocket around the target particle.A.
Endocytosis; B. Exocytosis; Endocytosis is a mechanism for internalizing large extracellular molecules (e.g., proteins), insoluble particles, or even microorganisms. The three main types of exocytosis are phagocytosis, pinocytosis and receptor-mediated tosis is non-specific. Phagocytosis targets large structures (e.g., bacteria, food particles) and is not particularly.This book elaborates on various aspects of targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases.
Targeted delivery relies on two basic approaches, passive and active targeting.